Understanding how T cells are affected in a specific immune disorder
Official title: Mechanisms Contributing to T Cell Immune Dysregulation in STAT3 Gain-of-Function
Funded at Washington University · NIH-10865631 · Data updated 2026-11-12
This study is looking at how the immune system works in people with STAT3 gain-of-function syndrome, a condition that causes early autoimmune issues, to better understand how certain immune cells interact and function, which could help improve diagnosis and treatment for those affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $195,894 |
| NIH project number | 1K08AI182483-01 |
| Project ID | NIH-10865631 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with STAT3 gain-of-function syndrome or related primary immune regulatory disorders.
✕Less likely to help
Patients with autoimmune disorders not related to STAT3 mutations may not benefit from this research.
What this research studies
This research investigates the mechanisms behind T cell immune dysregulation in patients with STAT3 gain-of-function syndrome, a condition that leads to early onset autoimmunity and multi-organ involvement. The study aims to explore the interactions between T and B cells, focusing on their development, polarization, and function. By utilizing advanced techniques like immunophenotyping and transcriptional analysis, the research seeks to uncover the specific cellular abnormalities that contribute to the disease. This knowledge could enhance diagnostic and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of autoimmune disorders linked to T cell dysregulation.
How similar studies have gone: Previous research has shown promising results in understanding immune dysregulation through similar cellular analysis approaches.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Schmitt, Erica G — Washington University
- Study coordinator: Schmitt, Erica G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.