Understanding how T cells affect skin cells in scleroderma
T cell-mediated control of dermal fibroblast gene programs and dysfunction in scleroderma
['FUNDING_R21'] · BENAROYA RESEARCH INST AT VIRGINIA MASON · NIH-11114053
This study is looking at how certain immune cells called T cells affect the worsening of scleroderma, a condition that causes hardening of the skin and organs, to help find new ways to treat its symptoms.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BENAROYA RESEARCH INST AT VIRGINIA MASON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11114053 on ClinicalTrials.gov |
What this research studies
This research investigates the role of T cells in the progression of scleroderma, a serious autoimmune disease that causes skin and organ fibrosis. By examining how T cells interact with fibroblasts, the cells responsible for producing connective tissue, the study aims to uncover the mechanisms behind the disease's pathology. The researchers will analyze different populations of T cells and their effects on fibroblast gene expression in both healthy and affected skin. This could lead to new insights into potential therapeutic targets for managing scleroderma symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with scleroderma who are experiencing symptoms related to skin and organ fibrosis.
Not a fit: Patients with other autoimmune diseases or those without a diagnosis of scleroderma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or alleviate the symptoms of scleroderma.
How similar studies have performed: Previous research has shown that targeting T cell interactions can lead to improvements in autoimmune conditions, suggesting potential for success in this approach.
Where this research is happening
SEATTLE, UNITED STATES
- BENAROYA RESEARCH INST AT VIRGINIA MASON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORAWSKI, PETER A — BENAROYA RESEARCH INST AT VIRGINIA MASON
- Study coordinator: MORAWSKI, PETER A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.