Understanding how T cells affect organ transplant success
Determinants of T Cell Fate in Transplantation Tolerance
This study is looking at how certain immune cells called memory CD8+ T cells can cause transplanted organs to be rejected, even when patients are on medication to prevent this, and it aims to find ways to help the body accept these organs better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10885955 on NIH RePORTER |
What this research studies
This research investigates the role of memory CD8+ T cells in organ transplantation, particularly how these cells contribute to the rejection of transplanted organs despite immunosuppressive treatments. By studying both animal models and human patients, the researchers aim to uncover the molecular mechanisms that regulate these T cells' responses. The project focuses on the inhibitory receptor FcγRIIB and its effects on T cell immunity, which could lead to improved strategies for achieving long-term transplant acceptance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have received or are awaiting organ transplants and may be at risk for organ rejection.
Not a fit: Patients who are not undergoing transplantation or those with conditions unrelated to organ rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments that enhance the success rate of organ transplants, potentially allowing patients to live with their transplants for longer periods without rejection.
How similar studies have performed: Previous research has shown promising results in understanding T cell behavior in transplantation, indicating that this approach has potential for significant advancements in the field.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Ford, Mandy L — Emory University
- Study coordinator: Ford, Mandy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.