Understanding how T cells affect intestinal stem cells during immune damage
Discriminating EGFR function in T cells and epithelium during immune-mediated tissue damage
This study is looking at how immune cells called T cells interact with the cells that help repair the gut, to see how they might cause damage in conditions like graft versus host disease and autoimmune disorders, with the hope of finding new ways to help patients heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10982147 on NIH RePORTER |
What this research studies
This research investigates the interactions between T cells and intestinal stem cells (ISCs) to understand how immune responses can lead to tissue damage, particularly in conditions like graft versus host disease (GVHD) and autoimmunity. The study explores how T cells infiltrate the ISC compartment and the mechanisms by which they can cause ISC death through cytokine signaling. By identifying pathways that promote epithelial regeneration, the research aims to translate these findings into potential clinical treatments for patients suffering from immune-mediated tissue damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing allogeneic bone marrow transplantation or those with autoimmune diseases.
Not a fit: Patients with conditions unrelated to immune-mediated tissue damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance tissue regeneration and improve outcomes for patients with immune-mediated conditions.
How similar studies have performed: Previous research has shown promising results in understanding immune interactions and developing treatments for GVHD, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Hanash, Alan M — Sloan-Kettering Inst Can Research
- Study coordinator: Hanash, Alan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.