Understanding how T cell receptor signaling affects autoimmune diseases
Dissecting the interactions between TCR signaling strength and inhibitory pathways
This study is looking at how certain signals in our immune system can go wrong and cause autoimmune diseases, with the hope of finding new ways to help people with these conditions feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11089374 on NIH RePORTER |
What this research studies
This research investigates the role of T cell receptor (TCR) signaling in autoimmune diseases, focusing on how inhibitory pathways can help maintain immune tolerance. The study aims to understand the mechanisms by which abnormal TCR signaling can lead to autoimmune conditions and how these pathways can be manipulated for therapeutic purposes. By analyzing specific genetic mutations that affect TCR signaling, the research seeks to uncover new insights that could lead to improved treatments for patients with autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases or those at risk of developing such conditions.
Not a fit: Patients with non-autoimmune conditions or those not affected by TCR signaling dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or even prevent autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding TCR signaling and its implications for autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Shen, Lin — University of Chicago
- Study coordinator: Shen, Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.