Understanding how T and B cells recognize sugars to improve treatments for bacterial diseases
Molecular basis of glycan recognition by T and B cells
['FUNDING_P01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11082440
This study is looking at how certain immune cells in your body recognize sugars from bacteria, with the goal of creating better treatments to help fight serious bacterial infections.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11082440 on ClinicalTrials.gov |
What this research studies
This research investigates the immune system's recognition of sugars (glycans) by T and B cells, which are crucial for fighting bacterial infections. By studying how these immune cells interact with glycans, the researchers aim to develop new immunotherapy strategies that could enhance the body's ability to respond to severe bacterial diseases. The project involves collaboration between chemists and biologists to create unique immunogens and reagents, allowing for in-depth studies of immune responses and the development of high-affinity antibodies. The findings could lead to optimized treatments that improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals, particularly children and the elderly, who are at risk for severe bacterial diseases.
Not a fit: Patients with non-bacterial infections or those who do not have a significant immune response to glycan recognition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy options that significantly improve the treatment of severe bacterial infections.
How similar studies have performed: Previous research has shown promise in using immunotherapy approaches for bacterial infections, suggesting that this line of investigation could yield significant advancements.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TEYTON, LUC — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: TEYTON, LUC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.