Understanding how α-synuclein affects iron levels in red blood cell production
Official title: α-Synuclein Regulation of the Erythroid Iron Restriction Response
Funded at University of Virginia · NIH-11159299 · Data updated 2026-11-12
This study is looking at how a protein called α-synuclein affects how our bodies handle iron deficiency, which can cause anemia, and aims to find better ways to treat people with conditions like polycythemia vera and kidney-related anemia by tailoring treatments to their specific needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $225,000 |
| NIH project number | 1R56DK141123-01 |
| Project ID | NIH-11159299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with iron deficiency anemia or those undergoing treatments that affect red blood cell production.
✕Less likely to help
Patients who do not have issues related to iron deficiency or anemia may not benefit from this research.
What this research studies
This research investigates how α-synuclein, a protein found in red blood cells, influences the body's response to iron deficiency, which can lead to iron deficiency anemia (IDA). The study aims to identify the pathways that regulate this response, as individuals can experience varying degrees of anemia despite similar levels of iron deficiency. By examining the interaction between α-synuclein and iron trafficking proteins, the research seeks to improve treatment strategies for conditions like polycythemia vera and anemia related to kidney failure. Patients may benefit from more personalized iron-targeting therapies based on their unique responses to iron deprivation.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients suffering from iron deficiency anemia.
How similar studies have gone: While the role of α-synuclein in red blood cells is not well-established, similar research has shown promise in understanding protein interactions in anemia, suggesting potential for success in this area.
Where this research is happening
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University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Goldfarb, Adam N. — University of Virginia
- Study coordinator: Goldfarb, Adam N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.