Understanding how SYNJ2 helps transport and translate mRNA in neurons
Dissecting How SYNJ2 Facilitates mRNA Targeting and Translation at Neuronal Mitochondria
This study is looking at how a protein called SYNJ2 helps move important messages in nerve cells to their energy centers, which is really important for keeping those cells healthy and working well.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11065904 on NIH RePORTER |
What this research studies
This research investigates the role of SYNJ2, a protein that binds to mRNA, in the transport and translation of specific mRNAs at neuronal mitochondria. By using advanced model systems, including genetically modified mice and human-derived neurons, the research aims to uncover the mechanisms that ensure proper mitochondrial function in neurons. The study will focus on identifying the sequences in mRNA that direct it to mitochondria and how SYNJ2 facilitates this process, which is crucial for neuronal health and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those affected by Amyotrophic Lateral Sclerosis.
Not a fit: Patients with acute neurological injuries or conditions unrelated to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of neurodegenerative diseases like Amyotrophic Lateral Sclerosis by improving our understanding of mitochondrial function in neurons.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dynamics in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Pena, Nicolai — Harvard Medical School
- Study coordinator: Pena, Nicolai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.