Understanding how SYNJ1 affects brain function and movement control
The Role of SYNJ1 in Dysregulating the Basal Ganglia Function
This study is looking at how changes in the SYNJ1 gene affect brain function and movement, especially in people with early-onset atypical Parkinsonism, to help understand why they might have motor problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10631066 on NIH RePORTER |
What this research studies
This research investigates the role of the SYNJ1 gene in regulating brain function, particularly in the basal ganglia, which is crucial for motor control. By studying mice with mutations in the SYNJ1 gene, the researchers aim to uncover how these mutations lead to motor deficits and other neurological issues. The approach involves examining the molecular and cellular mechanisms that contribute to these dysfunctions, focusing on synaptic transmission and calcium signaling in the brain. Patients with early-onset atypical Parkinsonism may find this research particularly relevant as it explores the underlying causes of their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with early-onset atypical Parkinsonism or those with a family history of related neurological disorders.
Not a fit: Patients with movement disorders not linked to SYNJ1 mutations or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for movement disorders associated with SYNJ1 mutations.
How similar studies have performed: Other research has shown promising results in understanding the role of synaptic genes in neurological disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Pan, Ping-Yue — Rutgers Biomedical and Health Sciences
- Study coordinator: Pan, Ping-Yue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.