Understanding how SYNGAP1 affects brain function in autism
Investigating Syngap1 as a regulator of striatal synaptic function
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10892153
This study is looking at how a gene called SYNGAP1 affects brain connections that control movement and behavior, which could help us understand the challenges faced by people with SYNGAP1-related intellectual disabilities and autism, ultimately aiming to improve their care and support.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10892153 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the SYNGAP1 gene in regulating synaptic function in the brain, particularly in the striatum, which is important for motor control and behavior. By using advanced techniques like CRISPR to manipulate gene expression, the researchers aim to understand how changes in SYNGAP1 contribute to symptoms seen in individuals with SYNGAP1-related intellectual disability and autism. The study will explore how the absence of SynGAP affects the strength and plasticity of synapses, which could lead to better insights into behavioral issues associated with autism. Patients may benefit from a deeper understanding of the biological mechanisms underlying their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with SYNGAP1-related intellectual disability or autism spectrum disorder.
Not a fit: Patients without SYNGAP1 mutations or those with unrelated neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing symptoms of autism and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of synaptic proteins in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BATEUP, HELEN S. — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: BATEUP, HELEN S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder