Understanding how SynGAP proteins work in the brain
Defining the architecture and activation mechanisms of SynGAP
['FUNDING_R21'] · IOWA STATE UNIVERSITY · NIH-10772178
This study is looking at a protein called SynGAP that helps our brains develop and learn, and it's for anyone interested in understanding how this protein works with others in the brain, which could help us find new ways to support people with mental health challenges like autism and schizophrenia.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | IOWA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (AMES, UNITED STATES) |
| Trial ID | NIH-10772178 on ClinicalTrials.gov |
What this research studies
This research investigates the structure and function of SynGAP, a protein that plays a crucial role in brain development and learning. By using advanced techniques like protein footprinting and spectroscopy, the team aims to uncover how SynGAP interacts with other proteins in the brain's synapses, which are essential for communication between nerve cells. The findings could provide insights into the molecular mechanisms behind mental health disorders such as autism and schizophrenia, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorders, schizophrenia, or intellectual disabilities, particularly those with known SynGAP mutations.
Not a fit: Patients without any genetic mutations related to SynGAP or those with unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for mental health disorders linked to SynGAP mutations.
How similar studies have performed: Other research has shown promising results in understanding protein interactions in synaptic signaling, suggesting that this approach could yield valuable insights.
Where this research is happening
AMES, UNITED STATES
- IOWA STATE UNIVERSITY — AMES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UNDERBAKKE, ERIC STEVEN — IOWA STATE UNIVERSITY
- Study coordinator: UNDERBAKKE, ERIC STEVEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental health disorders