Understanding how SYNE1-Giant affects heart rhythm disorders
Official title: Investigating the role of SYNE1-Giant in Atrial Cardiomyopathy
Funded at University of California, San Francisco · NIH-11071896 · Data updated 2026-11-12
This study is looking at how a protein called SYNE1-Giant affects heart rhythm problems like atrial fibrillation and sinus node dysfunction, with the goal of finding new ways to help people who struggle with these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $41,713 |
| NIH project number | 1F31HL178278-01 |
| Project ID | NIH-11071896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atrial fibrillation or sinus node dysfunction, particularly those with a family history of cardiac conditions.
✕Less likely to help
Patients with heart rhythm disorders not linked to genetic factors or those with other unrelated cardiac issues may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, SYNE1-Giant, in the development of atrial fibrillation and sinus node dysfunction, which are common heart rhythm disorders affecting millions. The study aims to uncover the mechanisms by which changes in heart muscle cells contribute to these conditions, focusing on how mechanical stress impacts gene expression and cell function. By exploring these pathways, the research seeks to identify potential therapeutic targets that could lead to new treatments for patients suffering from these heart rhythm issues.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat atrial fibrillation and sinus node dysfunction, improving heart health for many patients.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors associated with atrial fibrillation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Lally, Nav — University of California, San Francisco
- Study coordinator: Lally, Nav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.