Understanding how Syndecan-2 helps maintain and regenerate blood stem cells
The role of Syndecan-2 in hematopoietic stem cell maintenance and regeneration
This study is looking at a protein called Syndecan-2 to see how it helps blood stem cells recover and grow, especially after treatments like radiation or chemotherapy, with the hope of improving care for patients who need these treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11082342 on NIH RePORTER |
What this research studies
This research investigates the role of Syndecan-2, a specific protein, in the maintenance and regeneration of hematopoietic stem cells (HSCs), which are crucial for producing blood and immune cells. By using specialized mouse models, the researchers will explore how Syndecan-2 affects the ability of HSCs to engraft and recover from stress, such as radiation or chemotherapy. The findings aim to enhance our understanding of HSC biology and improve outcomes for patients undergoing treatments that impact blood cell production.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with blood cancers, immune disorders, or those requiring HSC transplants.
Not a fit: Patients with conditions unrelated to blood cell production or those not requiring HSC interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved HSC transplant outcomes and better recovery strategies for patients undergoing chemotherapy and radiation therapy.
How similar studies have performed: Previous research has shown that understanding the molecular mechanisms of stem cell maintenance can lead to significant advancements in transplantation success, indicating a promising avenue for this study.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Termini, Christina Marie — Fred Hutchinson Cancer Center
- Study coordinator: Termini, Christina Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.