Understanding how Syndecan-1 affects iron levels in the body
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
This study is looking at how a protein called Syndecan-1 affects a hormone that helps control iron in the body, which could lead to better treatments for people dealing with iron-related issues like anemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10987041 on NIH RePORTER |
What this research studies
This research investigates the role of Syndecan-1 in regulating hepcidin, a hormone that controls iron metabolism in the body. By studying human liver cells and animal models, the researchers aim to uncover how Syndecan-1 influences hepcidin expression and iron absorption. The goal is to develop new treatment strategies for conditions related to iron imbalance, such as anemia of inflammation. Patients may benefit from insights that could lead to improved therapies for managing their iron levels.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with anemia of chronic disease or inflammation, particularly those experiencing issues with iron metabolism.
Not a fit: Patients with iron overload conditions unrelated to hepcidin regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from iron-related disorders, improving their overall health and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding hepcidin regulation, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Gordts, Philip — University of California, San Diego
- Study coordinator: Gordts, Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.