Understanding how synaptic development is affected in neurodevelopmental disorders.
Axonal FMRP in Synaptic Development
This study is looking at how certain problems in brain connections happen in conditions like Fragile X syndrome, a type of autism, by using chicken embryos to see how changes in genes affect the way brain cells connect and communicate, with a special focus on a protein called FMRP that helps keep these connections healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10861769 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind abnormal synaptic development, particularly in conditions like Fragile X syndrome, which is a common inheritable form of autism. The study focuses on how disorganized synaptic adhesion and delayed assembly of synaptic vesicles can lead to developmental deficits in brain connectivity and function. Using chicken embryos as a model, researchers will manipulate genes and observe the effects on synaptic terminal formation and maturation. This approach aims to uncover the role of a specific protein, FMRP, in promoting healthy synaptic development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X syndrome or other related neurodevelopmental disorders.
Not a fit: Patients without neurodevelopmental disorders or those not affected by Fragile X syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for neurodevelopmental disorders like autism.
How similar studies have performed: Previous research has shown promising results in understanding synaptic development in related conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Wang, Yuan — Florida State University
- Study coordinator: Wang, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.