Understanding how synapses develop and function in the brain
Molecular and cellular mechanisms that underlie synaptic maturation
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-10684879
This study is looking at how connections between nerve cells in the brain grow and work properly, which is important for keeping our brains healthy, especially for people dealing with conditions like Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10684879 on ClinicalTrials.gov |
What this research studies
This research investigates the processes that allow synapses, the connections between nerve cells, to mature and function properly. It aims to identify the molecular mechanisms that facilitate this maturation, which is crucial for healthy brain function. By studying how synapses transition from simple to complex structures, the research seeks to uncover the genes and pathways involved in this process, particularly in relation to neurodegenerative diseases like Alzheimer's. Patients may benefit from insights gained into how synaptic failures contribute to various neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those with Alzheimer's disease or related conditions.
Not a fit: Patients with acute neurological injuries or those without neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases by enhancing our understanding of synaptic function and maturation.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms, but this specific focus on synaptic maturation in the context of neurodegenerative diseases is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOSCA, TIMOTHY J. — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: MOSCA, TIMOTHY J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease