Understanding how synapses change during learning and behavior
Official title: Examination of the cell biology of the synapse and behavior
Funded at Yale University · NIH-11084466 · Data updated 2026-11-12
This study looks at how the connections between brain cells change when we learn new things, helping us understand how memories are formed and how we adapt our behavior, and it's designed for anyone interested in how our brains work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,232,920 |
| NIH project number | 5R35NS132156-03 |
| Project ID | NIH-11084466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions affecting memory or learning processes.
✕Less likely to help
Patients with acute neurological injuries or conditions unrelated to synaptic function may not receive benefit from this research.
What this research studies
This research investigates the cell biology of synapses, which are crucial for communication between neurons, and how they adapt during learning to support various behaviors. By examining the structural organization of synapses and their modifications over time, the research aims to bridge the gap between molecular biology and behavioral outcomes. The approach involves studying the synaptic architecture at different scales, from individual cells to entire neural circuits, in living animals. This comprehensive analysis will enhance our understanding of memory formation and behavioral flexibility.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how memories are formed and retained, potentially informing treatments for memory-related disorders.
How similar studies have gone: Other research has shown success in understanding synaptic plasticity and its role in behavior, indicating that this approach is grounded in established scientific principles.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Colon-Ramos, Daniel a — Yale University
- Study coordinator: Colon-Ramos, Daniel a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.