Understanding how synapse changes affect memory loss in Alzheimer's disease
Synapse structural dynamics and memory loss in mouse models of Alzheimers disease
This study is looking at how changes in brain connections might cause memory loss in mice with Alzheimer's, hoping to find new ways to help people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-10599269 on NIH RePORTER |
What this research studies
This research investigates the relationship between synaptic strength and memory loss in mouse models of Alzheimer's disease. By examining the balance between excitatory and inhibitory synapses, the study aims to uncover how disruptions in this balance contribute to memory impairment. The researchers will utilize advanced techniques, including immunohistology and brain imaging, to analyze synaptic changes and neuronal activity in genetically predisposed mice. The ultimate goal is to identify the mechanisms behind memory loss, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to familial Alzheimer's disease.
Not a fit: Patients with non-genetic forms of Alzheimer's disease or other types of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for memory loss associated with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding synaptic changes in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Subramanian, Jaichandar — University of Kansas Lawrence
- Study coordinator: Subramanian, Jaichandar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.