Understanding how SWI/SNF complexes work in cancer
Mechanisms of SWI/SNF complex assembly and function
This study is looking at a group of proteins that help control how genes work, which can sometimes go wrong in about a quarter of cancers, to understand how their different parts interact and change, with the hope of finding new ways to treat these types of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11121174 on NIH RePORTER |
What this research studies
This research investigates the SWI/SNF chromatin remodeling complex, which is crucial for regulating gene expression and is mutated in about 25% of human tumors. The project aims to explore how different combinations of the complex's subunits affect its function and how these variations may contribute to cancer development. By examining post-translational modifications and interactions with RNA, the research seeks to uncover the mechanisms that regulate the activity of these complexes. The findings could lead to new therapeutic strategies for treating cancers associated with SWI/SNF mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that have mutations in the SWI/SNF complex.
Not a fit: Patients without SWI/SNF mutations or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for cancers linked to SWI/SNF mutations.
How similar studies have performed: Previous research has shown promising results in understanding chromatin remodeling complexes, indicating potential for breakthroughs in cancer treatment.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Raab, Jesse R. — Univ of North Carolina Chapel Hill
- Study coordinator: Raab, Jesse R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.