Understanding how SWI/SNF complexes affect gene regulation in tumors
Mechanisms of SWI/SNF complex assembly and function
This study is looking at a group of proteins that help control how genes work, which can be changed in some cancers, to understand how different combinations of these proteins might affect their role in cancer and help find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10880720 on NIH RePORTER |
What this research studies
This research investigates the SWI/SNF chromatin remodeling complex, which is crucial for regulating gene expression and is mutated in about 25% of human tumors. The project aims to understand how different combinations of SWI/SNF subunits create distinct complexes that may have unique functions in gene regulation. By exploring the mechanisms that control the assembly and activity of these complexes, the research seeks to uncover how mutations impact their function in cancer. The approach combines computational, molecular, and biochemical techniques to provide insights that could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that have mutations in the SWI/SNF complex.
Not a fit: Patients with tumors not associated with SWI/SNF mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for cancers associated with SWI/SNF mutations.
How similar studies have performed: Other research has shown promising results in understanding chromatin remodeling complexes, indicating that this approach has potential for success.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Raab, Jesse R. — Univ of North Carolina Chapel Hill
- Study coordinator: Raab, Jesse R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.