Understanding how SWELL1 affects muscle function and metabolism
SWELL1-LRRC8 mediated regulation of skeletal muscle function and metabolism
This study is looking at how a protein called SWELL1 helps keep our muscles healthy and strong, which is important for preventing weight-related health issues like diabetes and heart disease, and it aims to find new ways to improve treatments for muscle loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10830321 on NIH RePORTER |
What this research studies
This research investigates the role of SWELL1 in regulating skeletal muscle function and metabolism, which is crucial for maintaining muscle mass and preventing obesity-related diseases like diabetes and heart disease. The study focuses on the molecular mechanisms that control muscle growth and maintenance, particularly how SWELL1 interacts with signaling pathways that influence muscle health. By examining the effects of SWELL1 on muscle fiber size, exercise capacity, and overall metabolic health, the research aims to uncover new insights that could lead to better treatments for conditions associated with muscle atrophy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing muscle atrophy due to aging, chronic diseases, or conditions like cachexia and heart failure.
Not a fit: Patients with stable muscle mass and no underlying conditions affecting muscle function may not receive significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing muscle loss and improving metabolic health in patients, particularly the elderly and those with chronic diseases.
How similar studies have performed: Other research has shown promising results in understanding muscle metabolism and signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Sah, Rajan — Washington University
- Study coordinator: Sah, Rajan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.