Understanding how sweat glands develop and function
Official title: Molecular Mechanisms in Sweat Gland Development
Funded at New York University School of Medicine · NIH-11075329 · Data updated 2026-11-12
This study is looking at how sweat glands develop and work, especially for people who have had severe burns or have trouble sweating, to find new ways to help them regain their ability to sweat and stay cool.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $512,297 |
| NIH project number | 5R01AR080136-03 |
| Project ID | NIH-11075329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe burns or have conditions that impair their ability to sweat.
✕Less likely to help
Patients without any history of skin injuries or those who do not have issues with sweating may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind the development of eccrine sweat glands, which are crucial for regulating body temperature. It focuses on understanding the signaling pathways and mechanical factors that influence the formation of these glands, particularly in patients who have suffered severe burns or sweating deficiencies. By utilizing advanced techniques such as single-cell RNA sequencing and tissue culture systems, the research aims to uncover how epidermal progenitor cells differentiate into sweat glands. The findings could lead to new therapeutic strategies for regenerating sweat glands in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore sweat gland function in patients with sweating deficiencies.
How similar studies have gone: While the specific focus on sweat gland development is relatively novel, similar research in stem cell therapies has shown promising results in regenerative medicine.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lu, Catherine Pei-Ju — New York University School of Medicine
- Study coordinator: Lu, Catherine Pei-Ju
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.