Understanding how sweat glands develop and function
Genetic and Cellular Mechanisms of Engrailed-1 Regulation and Function in Eccrine Sweat Gland Development
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10831049
This study is looking into how our sweat glands develop and work, focusing on a specific protein called Engrailed-1, to help us understand how these glands help keep our body cool, which could be useful for anyone interested in skin health and temperature regulation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10831049 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and cellular mechanisms that drive the development of eccrine sweat glands, which are essential for regulating body temperature. By studying the transcription factor Engrailed-1, the research aims to identify the factors that influence the formation and differentiation of these glands. The approach combines in vivo testing with high-throughput analysis of human skin cells and mouse models to uncover the developmental processes involved. This work could lead to a better understanding of skin biology and the role of sweat glands in thermoregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting sweat gland function or thermoregulation.
Not a fit: Patients with no issues related to sweat gland function or thermoregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into sweat gland development that may lead to new treatments for conditions related to thermoregulation.
How similar studies have performed: Other research has shown success in understanding skin appendage development, making this approach promising.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAMBEROV, YANA G — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: KAMBEROV, YANA G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.