Understanding how SV40 virus enters human cells
Official title: Investigating the nuclear entry mechanism of SV40
Funded at University of Michigan at Ann Arbor · NIH-11089577 · Data updated 2026-11-12
This study is looking at how the SV40 virus gets into the center of human cells, which could help us find new ways to treat illnesses caused by similar viruses, like BK and JC viruses, so patients dealing with these conditions might benefit from what we learn.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $378,300 |
| NIH project number | 5R01AI179566-02 |
| Project ID | NIH-11089577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals suffering from conditions related to polyomaviruses, such as nephropathy, hemorrhagic cystitis, or progressive multifocal leukoencephalopathy.
✕Less likely to help
Patients with viral infections not related to polyomaviruses or those without any viral infections may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which the SV40 virus, a member of the polyomavirus family, enters the nucleus of human cells. By focusing on the roles of specific nuclear membrane protein complexes, the study aims to uncover the steps involved in viral entry, which is crucial for developing new treatments for diseases caused by related viruses, such as BK virus and JC virus. Patients with conditions linked to these viruses may benefit from insights gained through this research, as it could lead to novel therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for viral infections that affect the kidneys, nervous system, and skin.
How similar studies have gone: Other research has shown success in understanding viral entry mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Tsai, Billy — University of Michigan at Ann Arbor
- Study coordinator: Tsai, Billy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.