Understanding how SUMOylation affects the production of ribosomes in cells
Official title: SUMOylation regulation of ribosome biogenesis
Funded at Oregon Health & Science University · NIH-11124710 · Data updated 2026-11-12
This study is looking at how a special process that helps make ribosomes, which are important for cell growth, is controlled by a protein modification called SUMOylation, and it hopes to uncover how problems with this process can lead to certain diseases, helping patients understand the connection between ribosome production and their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM153360-02 |
| Project ID | NIH-11124710 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with ribosomopathies or related disorders affecting cell growth and function.
✕Less likely to help
Patients with conditions unrelated to ribosome biogenesis or SUMOylation may not receive any benefit from this research.
What this research studies
This research investigates the process of ribosome biogenesis, which is crucial for cell growth and proliferation. It focuses on how SUMOylation, a type of protein modification, regulates this process and how its disruption can lead to diseases known as ribosomopathies. By studying the roles of specific proteins involved in SUMOylation and deSUMOylation, the research aims to fill gaps in understanding the mechanisms that control ribosome production in healthy and diseased cells. Patients may benefit from insights gained into how ribosome production is linked to various health conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with ribosome biogenesis defects.
How similar studies have gone: Previous research has shown promising results in understanding the role of SUMOylation in cellular processes, indicating that this approach has potential for success.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Dai, Mu-Shui — Oregon Health & Science University
- Study coordinator: Dai, Mu-Shui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.