Understanding how sumoylation affects Sertoli cells in the testis
Sumoylation and its regulation in testicular Sertoli cells
This study is looking at how a specific protein affects the cells that support sperm production in men, with the goal of understanding male fertility better and finding new ways to help those facing infertility challenges.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yeshiva University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10654204 on NIH RePORTER |
What this research studies
This research investigates the role of sumoylation in Sertoli cells, which are crucial for male fertility. The study focuses on how the E3-SUMO ligase TRIM28 regulates the function of these cells and their interaction with germ cells. By examining the molecular changes that occur when TRIM28 is inactivated, the research aims to uncover the mechanisms behind testicular development and fertility issues. Patients may benefit from insights into male reproductive health and potential therapeutic targets for infertility.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include men experiencing infertility or related reproductive health issues.
Not a fit: Patients who are not experiencing fertility issues or have no interest in male reproductive health may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for male infertility.
How similar studies have performed: While the specific role of sumoylation in Sertoli cells is still being explored, similar research has shown promising results in understanding cellular regulation in other contexts.
Where this research is happening
New York, United States
- Yeshiva University — New York, United States (Active)
Researchers
- Principal investigator: Vigodner, Margarita — Yeshiva University
- Study coordinator: Vigodner, Margarita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.