Understanding how sumoylation affects Sertoli cells in the testis
Official title: Sumoylation and its regulation in testicular Sertoli cells
Funded at Yeshiva University · NIH-10654204 · Data updated 2026-11-12
This study is looking at how a specific protein affects the cells that support sperm production in men, with the goal of understanding male fertility better and finding new ways to help those facing infertility challenges.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yeshiva University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 5, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $450,000 |
| NIH project number | 1R15HD109736-01A1 |
| Project ID | NIH-10654204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include men experiencing infertility or related reproductive health issues.
✕Less likely to help
Patients who are not experiencing fertility issues or have no interest in male reproductive health may not receive benefit from this research.
What this research studies
This research investigates the role of sumoylation in Sertoli cells, which are crucial for male fertility. The study focuses on how the E3-SUMO ligase TRIM28 regulates the function of these cells and their interaction with germ cells. By examining the molecular changes that occur when TRIM28 is inactivated, the research aims to uncover the mechanisms behind testicular development and fertility issues. Patients may benefit from insights into male reproductive health and potential therapeutic targets for infertility.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for male infertility.
How similar studies have gone: While the specific role of sumoylation in Sertoli cells is still being explored, similar research has shown promising results in understanding cellular regulation in other contexts.
Where this research is happening
-
Yeshiva University
New York, United States Active
Researchers
- Principal investigator: Vigodner, Margarita — Yeshiva University
- Study coordinator: Vigodner, Margarita
Related research
Other NIH-funded projects on the same topics.
-
Mitochondrial liquid-liquid phase separation in Alzheimer's disease
A small NIH grant aims to understand how the Alzheimer’s-linked toxin Aβ42 affects mitochondrial function in cells, with the hope of guiding future treatments.
-
Intelligent Diet Pattern Analysis for Harmonized National Trials
A project to develop smart methods for tracking how diet quality changes over time across large studies to better understand diet and health.
-
Using digital mindfulness meditation to improve therapy for binge eating disorder
This study is testing a new online program that combines mindfulness meditation with traditional therapy to help people with binge eating disorder feel better and manage their eating habits more effectively.
-
Using reovirus to stimulate the immune system in colorectal cancer with KRAS mutations
This study is looking at how a virus called reovirus might help boost the immune system in people with colorectal cancer that has specific mutations, which can make the cancer harder to treat, with the hope of finding new ways to improve treatment for these patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.