Understanding how SUMO and ubiquitin help maintain genome stability
Defining Genome Stability Mechanisms and their Regulation by SUMO and Ubiquitin
This study is looking at how two proteins, SUMO and ubiquitin, help our cells fix DNA damage, which is important for keeping our genes healthy, and it could lead to new treatments for diseases like leukemia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10909269 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which SUMO and ubiquitin, two important proteins, regulate the DNA damage response in cells. By exploring how these proteins recruit and remove DNA repair factors, the study aims to uncover critical processes that maintain genetic integrity. The research focuses on specific proteins, STUbL and SMC5/6, which are involved in these regulatory pathways and have implications for diseases like leukemia. The findings could lead to new therapeutic strategies for conditions associated with genetic instability.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with genetic disorders or cancers related to DNA damage and repair mechanisms.
Not a fit: Patients with conditions unrelated to genetic stability or DNA repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by genetic instability, such as certain cancers.
How similar studies have performed: Previous research has shown promising results in understanding the roles of SUMO and ubiquitin in DNA repair, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Boddy, Michael N — Scripps Research Institute, the
- Study coordinator: Boddy, Michael N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.