Understanding how sulfotyrosine affects protein interactions and immune responses
Official title: Sulfotyrosine, an essential determinant for diverse protein-protein interactions
Funded at University of California at Davis · NIH-11000815 · Data updated 2026-11-12
This study is looking at how a special chemical change in proteins can help us understand how HIV gets into our cells and how our immune system reacts to germs, with the goal of finding better treatments for HIV and heart-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $383,431 |
| NIH project number | 5R35GM148173-03 |
| Project ID | NIH-11000815 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV or those affected by cardiovascular diseases related to blood clotting.
✕Less likely to help
Patients with conditions unrelated to HIV or cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the role of tyrosine sulfation, a chemical modification that influences various biological functions, including how HIV enters human cells and how immune receptors interact with microbial molecules. The project aims to isolate and characterize the receptors that bind to sulfated peptides and develop methods to produce these therapeutic molecules efficiently. By exploring these interactions, the research seeks to enhance our understanding of immune responses and potential treatments for conditions like cardiovascular diseases and HIV.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating HIV and improving blood clotting disorders.
How similar studies have gone: Previous research has shown promise in understanding protein interactions and immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Ronald, Pamela C — University of California at Davis
- Study coordinator: Ronald, Pamela C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.