Understanding how sulfide affects metabolism and signaling in the body
Sulfide metabolism and signaling
This study is looking at how the food we eat affects a substance called sulfide in our gut and how that, in turn, influences our body's energy and communication between cells, especially for those interested in gut health and metabolism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11001152 on NIH RePORTER |
What this research studies
This research investigates the role of sulfide in metabolism and its signaling pathways, particularly focusing on how diet influences sulfide levels in the gut and its systemic effects. By examining the interactions between gut microbiota and host cells, the study aims to uncover the mechanisms by which sulfide impacts cellular processes, including energy production and cell communication. The research employs advanced techniques such as metabolomics, RNA sequencing, and CRISPR interference to analyze these complex biological interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders or those at risk for colorectal cancer.
Not a fit: Patients with no metabolic issues or those not affected by colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into metabolic disorders and potential therapeutic strategies for conditions like colorectal cancer.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways influenced by gut microbiota, suggesting that this approach could yield significant findings.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Banerjee, Ruma V — University of Michigan at Ann Arbor
- Study coordinator: Banerjee, Ruma V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.