Understanding how sugars on proteins affect Alzheimer's disease and related disorders.
Official title: Decoding the role of the glycoproteome in Alzheimer’s disease and related disorders.
Funded at Rutgers Biomedical and Health Sciences · NIH-11054096 · Data updated 2026-11-12
This study is looking at how certain proteins with sugar molecules might affect Alzheimer's disease and whether staying active can help keep your brain healthy, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $795,436 |
| NIH project number | 1R01AG091534-01 |
| Project ID | NIH-11054096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-Alzheimer's related cognitive impairments or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of glycoproteins, which are proteins with sugar molecules attached, in the development and progression of Alzheimer's disease and related disorders. By utilizing a novel method to analyze the glycoproteome, the study aims to identify specific glycopeptiforms that are linked to cognitive decline and other clinical traits associated with Alzheimer's. The research will also explore how an active lifestyle may influence brain health through these glycopeptiforms. This comprehensive approach could lead to new insights into the mechanisms of Alzheimer's and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve cognitive function and mobility in patients with Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of proteins in Alzheimer's, but this specific approach to studying the glycoproteome is relatively novel.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Schnaider Beeri, Michal — Rutgers Biomedical and Health Sciences
- Study coordinator: Schnaider Beeri, Michal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.