Understanding how sugars on cells affect cholera toxin binding
Function and regulation of epithelial glycosylation
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11046358
This study is looking at how certain sugars on our cells interact with the cholera toxin, which can help us understand why some people are more likely to get sick from cholera than others, especially based on their blood type.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11046358 on ClinicalTrials.gov |
What this research studies
This research investigates the biological roles of glycoconjugates, particularly how they interact with cholera toxin and affect host cell intoxication. The team is developing chemical biology tools to study these interactions and aims to determine the molecular structure of specific glycoconjugates recognized by cholera toxin. Additionally, the research will explore how different ABO blood group types influence the binding of cholera toxin to host cells. This work could provide insights into individual variations in susceptibility to cholera and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with varying ABO blood group types, particularly those interested in understanding their susceptibility to cholera.
Not a fit: Patients who do not have any ABO blood group variations or those not affected by cholera or related gastrointestinal diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cholera infection mechanisms and potentially inform new treatment strategies.
How similar studies have performed: Other research has shown success in understanding glycan interactions with pathogens, suggesting that this approach may yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOHLER, JENNIFER J — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: KOHLER, JENNIFER J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.