Understanding how sugars influence blood cell production in the bone marrow
Official title: Molecular and Clinical Glycobiology of the Bone Marrow Environment
Funded at Versiti Wisconsin, INC. · NIH-11001969 · Data updated 2026-11-12
This study is looking at how certain sugars in your body help make and manage blood cells in the bone marrow, which could lead to new ways to treat blood disorders.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $2,213,925 |
| NIH project number | 5P01HL151333-05 |
| Project ID | NIH-11001969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with blood disorders or conditions affecting blood cell production.
✕Less likely to help
Patients with stable blood cell counts and no underlying blood disorders may not benefit from this research.
What this research studies
This research investigates the role of specific sugars, known as glycans, in the production and function of blood cells within the bone marrow. It aims to uncover how these sugars affect the fate and activity of hematopoietic progenitor cells, which are crucial for generating blood cells. By using advanced techniques and collaborative approaches, the research will explore the mechanisms by which glycans regulate the development of megakaryocytes, the cells responsible for producing platelets. This could lead to a better understanding of blood cell formation and potential treatments for blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for blood disorders by enhancing our understanding of blood cell production.
How similar studies have gone: Previous research has shown promising results in understanding the role of glycans in blood cell development, indicating that this approach has potential for success.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Hoffmeister, Karin Maria — Versiti Wisconsin, INC.
- Study coordinator: Hoffmeister, Karin Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.