Understanding how sugar transport affects C. difficile infections
The role of sugar transport in C. difficile colonization and disease
This study is looking at how certain sugars help the bacteria Clostridioides difficile grow in the gut and cause illness, with the hope of finding new ways to prevent and treat infections for people affected by this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11038022 on NIH RePORTER |
What this research studies
This research investigates how the transport of sugars in the bacteria Clostridioides difficile influences its ability to colonize the gut and cause disease. By examining the specific sugar transporters that C. difficile uses, the researchers aim to understand how dietary sugars may affect the bacteria's behavior and its impact on health. The study will involve laboratory experiments to identify key transporters and their roles in infection and disease progression. Ultimately, the goal is to find new ways to prevent and treat C. difficile infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older who are at risk for or have experienced C. difficile infections.
Not a fit: Patients under the age of 21 or those without a history of C. difficile infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments and preventive strategies for C. difficile infections, which are a significant health concern, especially in older adults.
How similar studies have performed: Previous research has shown that targeting bacterial metabolism can lead to successful treatment strategies, suggesting potential for success in this novel approach.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Collins, James Tristan — University of Louisville
- Study coordinator: Collins, James Tristan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.