Understanding how sugar molecules on proteins affect blood clotting and inflammation in sepsis
Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis
['FUNDING_P01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-11110302
This work aims to uncover the molecular changes in blood and blood vessels that contribute to sepsis, a life-threatening condition.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11110302 on ClinicalTrials.gov |
What this research studies
Sepsis is a severe illness caused by infections, leading to widespread inflammation, blood clotting problems, and organ damage. Despite its high mortality and long-term disabilities for survivors, new treatments have not emerged in decades. This program brings together scientists and doctors to explore the molecular details of sepsis, moving beyond simply describing the disease. We are looking at how changes to proteins in the blood and blood vessels, particularly involving sugar molecules, contribute to the illness. By understanding these fundamental processes, we hope to find new ways to protect patients from the devastating effects of sepsis.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients at this stage, but future clinical applications would target individuals suffering from sepsis.
Not a fit: Patients not affected by sepsis or related blood coagulation disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and more effective treatments for sepsis, potentially reducing mortality and long-term disabilities.
How similar studies have performed: While sepsis research is ongoing, this program focuses on novel molecular approaches to address the current lack of effective therapies.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARTH, JAMEY — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: MARTH, JAMEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Coagulation Disorders