Understanding how sugar modifications affect malaria parasites
Elucidating the role of TSR glycosylation in Plasmodium parasites
This study is looking at how certain sugars on proteins help malaria parasites stick to and invade our cells, which could help scientists find new ways to prevent malaria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10880247 on NIH RePORTER |
What this research studies
This research investigates the role of specific sugar modifications on proteins in malaria-causing parasites called Plasmodium. By studying how these modifications influence the parasites' ability to attach to and invade host cells, researchers aim to uncover critical aspects of the parasite's life cycle. The approach involves advanced techniques like mass spectrometry to analyze the glycosylation patterns of proteins at different stages of the parasite's development. This knowledge could lead to new strategies for preventing malaria infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of malaria infection, particularly those living in endemic regions.
Not a fit: Patients who are not at risk of malaria or those who have already been infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new vaccines or treatments for malaria, potentially saving countless lives.
How similar studies have performed: Other research has shown promising results in understanding the role of protein modifications in various pathogens, suggesting that this approach could yield valuable insights for malaria as well.
Where this research is happening
Seattle, United States
- Institute for Systems Biology — Seattle, United States (Active)
Researchers
- Principal investigator: Swearingen, Kristian Edward — Institute for Systems Biology
- Study coordinator: Swearingen, Kristian Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.