Understanding how succinate affects metabolism and inflammation in tissues
Defining mechanisms of extracellular succinate regulation over metabolic tissue function
This study is looking at how a substance called succinate affects our body's metabolism and inflammation, especially in fat and muscle cells, to see if it can help manage or prevent conditions like diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10801130 on NIH RePORTER |
What this research studies
This research investigates the role of succinate, a metabolite produced by cells, in regulating metabolic functions and inflammation. It focuses on how succinate interacts with specific receptors in different cell types, particularly in brown adipose tissue and muscle cells, to understand its protective and harmful effects. By examining how the duration of succinate exposure influences its impact on these cells, the research aims to uncover the mechanisms that determine whether succinate promotes health or contributes to disease. Patients may benefit from insights into how metabolic disorders, such as diabetes, can be managed or prevented.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders, such as diabetes or obesity, who may be affected by inflammation and metabolic dysfunction.
Not a fit: Patients who do not have metabolic disorders or related inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic disorders and inflammation-related conditions.
How similar studies have performed: Previous research has shown that understanding metabolic signaling pathways can lead to significant advancements in treating metabolic diseases, suggesting that this approach has potential for success.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Chouchani, Edward Thomas — Dana-Farber Cancer Inst
- Study coordinator: Chouchani, Edward Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.