Understanding how substance use and depression affect people living with HIV
Integrated neuroimmune model of problematic substance use and depression in people living with HIV
This study is looking at how substance use and depression affect young adults living with HIV, and how inflammation in the body might play a role, with the goal of finding ways to improve mental health and help people stick to their treatment plans.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11051114 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between substance use, depression, and systemic inflammation in individuals living with HIV, particularly during young adulthood. It aims to identify the factors that contribute to these issues, which are prevalent among this population and can lead to chronic diseases. By examining the brain's central executive network, the study seeks to understand how lower brain function may increase vulnerability to stress and negative emotions, thereby exacerbating substance use and depression. The findings could help develop targeted interventions to improve mental health and treatment adherence.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults living with HIV who are experiencing substance use and depression.
Not a fit: Patients who are not living with HIV or who do not have issues related to substance use or depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved mental health outcomes and better adherence to HIV treatment for patients.
How similar studies have performed: Other research has shown promising results in understanding the interplay between mental health and chronic diseases in HIV populations, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Schrock, Joshua Matthew — Northwestern University at Chicago
- Study coordinator: Schrock, Joshua Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.