Understanding how structural variations in genes evolve
Official title: Learning about the evolution of structural variations from genomic and transcriptomic data
Funded at Florida Atlantic University · NIH-10850583 · Data updated 2026-11-12
This study looks at how changes in our genes, like when genes get duplicated, can affect evolution and lead to diseases, and it's for anyone curious about how these genetic changes impact our bodies and health over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | August 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $373,597 |
| NIH project number | 5R35GM142438-04 |
| Project ID | NIH-10850583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases linked to structural variations in their DNA.
✕Less likely to help
Patients without any known genetic disorders or those not affected by structural variations may not benefit from this research.
What this research studies
This research investigates how structural variations in genes, such as gene duplications, contribute to evolutionary changes and human diseases. By analyzing genomic and transcriptomic data, the team uses computational methods to classify the evolutionary outcomes of these variations. The research focuses on understanding how gene duplications affect gene expression across different tissues and species, particularly in organisms like Drosophila and mammals. This approach aims to uncover the role of natural selection in shaping these genetic changes over time.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of genetic factors in diseases and inform new therapeutic strategies.
How similar studies have gone: Previous research has shown success in understanding gene duplications and their evolutionary impacts, indicating that this approach is grounded in established scientific methods.
Where this research is happening
-
Florida Atlantic University
Boca Raton, United States Active
Researchers
- Principal investigator: Assis, Raquel — Florida Atlantic University
- Study coordinator: Assis, Raquel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.