Understanding how structural changes in DNA affect gene regulation in cancer
Investigating the effects of structural variants on 3D genome organization and gene regulation in cancer genomes
['FUNDING_U01'] · SALK INSTITUTE FOR BIOLOGICAL STUDIES · NIH-10904726
This study is looking at how changes in our DNA structure can affect how our genes work and may play a role in cancer, with the hope that the findings will help patients understand more about their condition.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SALK INSTITUTE FOR BIOLOGICAL STUDIES (nih funded) |
| Locations | 1 site (La Jolla, UNITED STATES) |
| Trial ID | NIH-10904726 on ClinicalTrials.gov |
What this research studies
This research investigates how structural variants in the genome, such as mutations and rearrangements, impact the three-dimensional organization of DNA within cells and subsequently influence gene regulation. By utilizing advanced techniques, including CRISPR, the study aims to explore the relationship between these structural changes and their effects on gene expression, particularly in the context of cancer. Patients may benefit from insights gained about how these mutations contribute to cancer development and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with specific types of cancer that may be influenced by structural variants in their genomes.
Not a fit: Patients with cancers not associated with structural genomic changes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating cancers linked to structural genomic changes.
How similar studies have performed: Previous research has shown promising results in understanding the role of structural variants in gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
La Jolla, UNITED STATES
- SALK INSTITUTE FOR BIOLOGICAL STUDIES — La Jolla, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIXON, JESSE R — SALK INSTITUTE FOR BIOLOGICAL STUDIES
- Study coordinator: DIXON, JESSE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.