Understanding how stroke affects pneumonia risk and recovery
Official title: Reciprocal brain-lung responses in post-stroke pneumonia
Funded at Yale University · NIH-10894099 · Data updated 2026-11-12
This study is looking at how having a stroke might make patients more likely to get serious pneumonia, and it aims to find new ways to help stroke survivors recover better by understanding how their bodies react to infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $209,375 |
| NIH project number | 5R21NS134229-02 |
| Project ID | NIH-10894099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke and are at risk for pneumonia.
✕Less likely to help
Patients who have not had a stroke or those with pre-existing severe respiratory conditions may not benefit from this research.
What this research studies
This research investigates the connection between stroke and the increased risk of severe pneumonia in patients. It involves a collaborative approach from experts in neurology and pulmonary care to explore how stroke impacts immune responses and inflammation in the lungs and brain. By studying the mechanisms behind pneumonia development after a stroke, the research aims to identify new treatment targets that could improve recovery outcomes for stroke patients. The project utilizes experimental models to analyze how bacterial infections interact with stroke-related changes in the body.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of pneumonia and improve recovery for stroke patients.
How similar studies have gone: Previous research has shown promising results in understanding the immune response in stroke patients, indicating that this approach could lead to significant advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Sansing, Lauren H — Yale University
- Study coordinator: Sansing, Lauren H
Related research
Other NIH-funded projects on the same topics.
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This study is testing a new device that helps people who have trouble swallowing after a stroke by stimulating certain nerves, which could make it easier for them to eat and lower their chances of getting pneumonia.
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A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
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This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
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BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.