Understanding how stress responses in cells affect breast cancer metabolism
Crosstalk Between the ER Stress Response and Mitochondrial Fatty Acid Oxidation in MYC-driven Breast Cancer
This study is looking at how breast cancer cells, especially those influenced by the MYC gene, handle stress and use energy, with the hope of finding new ways to treat the cancer and help patients feel better.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11169278 on NIH RePORTER |
What this research studies
This research investigates the relationship between cellular stress responses and energy metabolism in breast cancer, particularly focusing on a type of breast cancer driven by the MYC gene. The study aims to understand how the endoplasmic reticulum (ER) communicates with mitochondria and the nucleus to influence cancer cell behavior. By examining the role of specific proteins involved in this communication, the research seeks to identify potential new treatments that could disrupt cancer growth and improve patient outcomes. Patients may benefit from insights gained about how their cancer cells respond to stress and how this affects treatment resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with MYC-overexpressing triple negative breast cancer (TNBC).
Not a fit: Patients with breast cancer that does not involve MYC overexpression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating MYC-driven breast cancer, potentially improving survival rates.
How similar studies have performed: Previous studies have shown promising results in targeting metabolic pathways in cancer, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Chen, Xi — University of Tx Md Anderson Can Ctr
- Study coordinator: Chen, Xi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.