Understanding how stress responses help maintain healthy tissues
Official title: Elucidating the role of the Integrated Stress Response pathway in tissue homeostasis
Funded at University of Pittsburgh at Pittsburgh · NIH-10928760 · Data updated 2026-11-12
This study looks at how a special process in our cells helps them handle stress and stay healthy, using fruit flies to learn more about how this works in fat and ovarian tissues, which could help us understand stress-related issues in people, like diabetes and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 13, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $394,727 |
| NIH project number | 5R35GM150516-02 |
| Project ID | NIH-10928760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or conditions influenced by cellular stress responses.
✕Less likely to help
Patients with conditions unrelated to cellular stress or tissue homeostasis may not benefit from this research.
What this research studies
This research investigates how the Integrated Stress Response (ISR) pathway helps cells adapt to stress and maintain tissue health. By using Drosophila as a model organism, the study will explore the molecular mechanisms of ISR signaling in various cell types, particularly focusing on fat and ovarian tissues. The research aims to uncover how these stress responses function at a cellular level, which could provide insights into their roles in human health and disease. Patients may benefit from a better understanding of how cellular stress impacts conditions like diabetes and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cellular stress, such as diabetes and certain cancers.
How similar studies have gone: Previous research has shown that understanding stress response pathways can lead to significant advancements in treating metabolic and cancer-related diseases.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Vasudevan, Deepika — University of Pittsburgh at Pittsburgh
- Study coordinator: Vasudevan, Deepika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.