Understanding how stress-related proteins and RNA affect ALS and frontotemporal dementia
Investigating Dysregulation of Stress-related Ribonucleoprotein Granules and Functions of Associated RNA-binding Proteins in ALS/FTD
This study is looking at how certain proteins behave in the brain during conditions like ALS and frontotemporal dementia, hoping to find new ways to help people with these conditions by understanding what goes wrong at a molecular level.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11003341 on NIH RePORTER |
What this research studies
This research investigates the role of ribonucleoprotein granules and RNA-binding proteins in the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). By examining how these proteins misfold and aggregate under stress conditions, the study aims to uncover the underlying mechanisms that contribute to neurodegeneration. The approach includes a combination of genetic, biochemical, and pathological analyses to better understand the functions of these proteins and their impact on cellular processes. Patients may benefit from insights that could lead to new therapeutic strategies targeting these molecular pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS or FTD, as well as those with related neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases not related to ALS or FTD may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of ALS and FTD.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA-binding proteins in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wang, Jiou — Johns Hopkins University
- Study coordinator: Wang, Jiou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.