Understanding how stress in heart cell mitochondria affects heart function
Delineate the Pathophysiological Effect of Cardiomyocyte-specific Mitochondrial Stress
This study is looking at how problems with tiny parts of heart cells, called mitochondria, can affect heart function, and it's for anyone interested in understanding heart failure better, as the researchers are using new technology to explore ways to improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10868479 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial dysfunction in heart failure, focusing specifically on how stress in heart cell mitochondria impacts heart function. The team has developed a novel technology that allows for precise manipulation of mitochondrial activity in heart cells, enabling them to study the effects of mitochondrial stress on energy production and heart cell behavior. By using this innovative approach, they aim to uncover the mechanisms that link mitochondrial dysfunction to heart failure, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure due to mitochondrial dysfunction.
Not a fit: Patients with heart failure caused by non-mitochondrial factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure that target mitochondrial dysfunction.
How similar studies have performed: While mitochondrial dysfunction is a known factor in heart failure, this specific approach using luminoptogenetic technology is novel and has not been extensively tested in clinical settings.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Zhou, Lufang — Ohio State University
- Study coordinator: Zhou, Lufang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.