Understanding how stress in cells contributes to the growth of abdominal aortic aneurysms
Official title: The Role of the Endoplasmic Reticulum Stress Response in Abdominal Aortic Aneurysm Development
Funded at Veterans Health Administration · NIH-11048771 · Data updated 2026-11-12
This study is looking at how stress in cells might cause abdominal aortic aneurysms (AAAs) to grow, especially in veterans, by exploring how immune cells and blood vessel cells interact, so we can better understand what happens in this serious condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| NIH project number | 1IK2BX006562-01A1 |
| Project ID | NIH-11048771 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans or individuals at risk for abdominal aortic aneurysms, particularly those with a history of vascular diseases.
✕Less likely to help
Patients who do not have abdominal aortic aneurysms or related vascular conditions may not benefit from this research.
What this research studies
This research investigates the role of cellular stress responses in the development of abdominal aortic aneurysms (AAAs), a serious vascular condition prevalent among veterans. By examining the interactions between immune cells and vascular smooth muscle cells, the study aims to uncover the molecular mechanisms that lead to AAA expansion. Utilizing advanced techniques like single-cell RNA sequencing and animal models, the researchers will explore how specific stress pathways in cells contribute to cell dysfunction and death, which may drive the progression of AAAs.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent the growth of abdominal aortic aneurysms, potentially saving lives.
How similar studies have gone: Previous research has shown promising results in understanding cellular stress responses in other vascular conditions, suggesting potential for success in this area as well.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Davis, Frank Michael — Veterans Health Administration
- Study coordinator: Davis, Frank Michael
Related research
Other NIH-funded projects on the same topics.
-
How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
MOF’s role in weakening the aorta and stopping aneurysm growth
Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
-
Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
-
Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
-
Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.