Understanding how stress in cells contributes to the growth of abdominal aortic aneurysms
The Role of the Endoplasmic Reticulum Stress Response in Abdominal Aortic Aneurysm Development
This study is looking at how stress in cells might cause abdominal aortic aneurysms (AAAs) to grow, especially in veterans, by exploring how immune cells and blood vessel cells interact, so we can better understand what happens in this serious condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11048771 on NIH RePORTER |
What this research studies
This research investigates the role of cellular stress responses in the development of abdominal aortic aneurysms (AAAs), a serious vascular condition prevalent among veterans. By examining the interactions between immune cells and vascular smooth muscle cells, the study aims to uncover the molecular mechanisms that lead to AAA expansion. Utilizing advanced techniques like single-cell RNA sequencing and animal models, the researchers will explore how specific stress pathways in cells contribute to cell dysfunction and death, which may drive the progression of AAAs.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans or individuals at risk for abdominal aortic aneurysms, particularly those with a history of vascular diseases.
Not a fit: Patients who do not have abdominal aortic aneurysms or related vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent the growth of abdominal aortic aneurysms, potentially saving lives.
How similar studies have performed: Previous research has shown promising results in understanding cellular stress responses in other vascular conditions, suggesting potential for success in this area as well.
Where this research is happening
Ann Arbor, United States
- Veterans Health Administration — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Davis, Frank Michael — Veterans Health Administration
- Study coordinator: Davis, Frank Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.