Understanding how stress in cells affects pain
Endoplasmic Reticulum Stress Responses in Pain
This study is looking at how stress in certain cells affects pain after nerve injuries, and it's for people who want to understand why they might still feel pain long after getting hurt.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10808953 on NIH RePORTER |
What this research studies
This research investigates the role of endoplasmic reticulum (ER) stress responses in the development and persistence of pain following peripheral nerve injury. It focuses on how immune cells respond to injury by activating certain receptors, leading to inflammation and pain. The study uses genetically modified mice to explore the effects of specific cellular pathways on pain responses and recovery. By analyzing gene expression and protein production in these cells, the research aims to uncover new mechanisms that contribute to chronic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions related to nerve injuries.
Not a fit: Patients with acute pain not related to nerve injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain by targeting the cellular mechanisms involved in pain persistence.
How similar studies have performed: Previous research has shown that targeting cellular stress responses can lead to improvements in pain management, indicating potential success for this approach.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Romero-Sandoval, E. Alfonso — Wake Forest University Health Sciences
- Study coordinator: Romero-Sandoval, E. Alfonso
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.