Understanding how stress in cells affects mitochondria in Alzheimer's disease
Defining Endoplasmic Reticulum Stress-Development Mitochondria Remodeling
This study is looking at how stress in a part of our cells called the endoplasmic reticulum affects the energy-producing parts of our cells, especially in people with Alzheimer's disease, to find new ways to help improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10537152 on NIH RePORTER |
What this research studies
This research investigates the relationship between endoplasmic reticulum (ER) stress and mitochondrial dysfunction in neurodegenerative diseases, particularly Alzheimer's disease. It aims to understand how the PERK signaling pathway responds to different levels of ER stress and how this affects mitochondrial health and function. By examining the cellular mechanisms involved, the study seeks to identify potential therapeutic targets that could improve outcomes for patients with Alzheimer's and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
Not a fit: Patients with non-neurodegenerative conditions or those without a diagnosis of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain cells and improve the quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of ER stress in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wiseman, Rockland Luke — Scripps Research Institute, the
- Study coordinator: Wiseman, Rockland Luke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.