Understanding how stress granules affect leukemia stem cells
Official title: Dissecting stress granule dependencies in leukemia stem cells
Funded at University of California, San Diego · NIH-10877718 · Data updated 2026-11-12
This study is looking at how tiny structures in cells, called stress granules, help leukemia stem cells survive and grow in acute myeloid leukemia, with the hope of finding better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $432,496 |
| NIH project number | 5R01CA273432-02 |
| Project ID | NIH-10877718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those with treatment-resistant forms of the disease.
✕Less likely to help
Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
What this research studies
This research investigates the role of stress granules in the survival and proliferation of leukemia stem cells (LSCs) in acute myeloid leukemia (AML). By utilizing advanced genetic screening techniques and in vivo studies, the researchers aim to uncover how these cellular structures contribute to the persistence of treatment-resistant LSCs. The study focuses on the molecular mechanisms that govern RNA metabolism and gene expression in LSCs, which could lead to new therapeutic strategies. Patients may benefit from insights that could improve treatment outcomes for AML.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target leukemia stem cells, potentially improving survival rates for AML patients.
How similar studies have gone: Other research has shown promising results in targeting RNA metabolism in cancer cells, suggesting that this approach may hold potential for AML treatment.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Yeo, Eugene Wei-Ming — University of California, San Diego
- Study coordinator: Yeo, Eugene Wei-Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.