Understanding how stress damages mitochondria in cells
Official title: Molecular Mechanisms of Stress-Induced Mitochondrial Damage
Funded at Albert Einstein College of Medicine · NIH-11021305 · Data updated 2026-11-12
This study looks at how stress can harm the tiny powerhouses in our cells called mitochondria, which help produce energy, and it aims to find out how this damage might lead to cell death, potentially helping patients understand their health better and discover new ways to treat related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $420,000 |
| NIH project number | 1R35GM156982-01 |
| Project ID | NIH-11021305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions associated with mitochondrial dysfunction, such as neurodegenerative diseases or cardiovascular issues.
✕Less likely to help
Patients with non-mitochondrial related conditions or those not experiencing stress-induced cellular damage may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind mitochondrial dysfunction caused by stress, focusing on how this affects energy production in cells. By examining the process of oxidative phosphorylation, the study aims to uncover how disruptions in mitochondrial integrity can lead to cell death. The research employs cellular models to explore the role of calcium and reactive oxygen species in mitochondrial damage, which could provide insights into various degenerative diseases. Patients may benefit from a better understanding of how stress impacts their health and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to mitochondrial dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Neginskaya, Maria a — Albert Einstein College of Medicine
- Study coordinator: Neginskaya, Maria a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.