Understanding how stress and genetics affect mental health traits
Official title: Modeling the interaction of physiological and environmental stressors on common variants to psychiatric traits
Funded at Yale University · NIH-11011317 · Data updated 2026-11-12
This study looks at how your genes and life stress can affect mental health and brain function, helping us understand how these factors work together, so we can find better, more personalized treatments for conditions like depression or Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $993,652 |
| NIH project number | 5R01ES033630-04 |
| Project ID | NIH-11011317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of psychiatric or neurodegenerative disorders or those experiencing significant environmental stressors.
✕Less likely to help
Patients with no genetic predisposition to psychiatric or neurodegenerative disorders or those not experiencing environmental stressors may not benefit from this research.
What this research studies
This research investigates how both genetic variations and environmental stressors contribute to psychiatric and neurodegenerative disorders. By examining the interactions between these factors, the study aims to uncover the underlying biological mechanisms that link genetic risk to brain function. Patients may benefit from insights into how their genetic makeup and life stressors could influence their mental health, potentially leading to more personalized treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals with psychiatric and neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in understanding the interplay between genetics and environmental factors in mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Huckins, Laura Marianne — Yale University
- Study coordinator: Huckins, Laura Marianne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.